8. Resident Evil - Picking Chris Over Jill
At the start of the first Resident Evil game, picking from a choice of two characters seems like a purely cosmetic one. They're new to us, we haven't yet discovered their origins or strengths, so it seems like a binary choice.
Oh how wrong we were.
On paper, Chris Redfield looks like the "standard" choice. Not out of sexism, just that he looks like he'd be able to handle himself. Yet unbeknownst to many, picking the bulkier looking member of S.T.A.R.S is actually the game's 'hard mode'.
He may take more hits to weaken, but a smaller inventory than Jill, as well as not as many assisted opportunities leave Chris doing a lot by himself. No easy shotgun, certainly no grenade launcher, as well as plenty of backtracking and item juggling make this more of a challenge.
Of course, had he been your first choice, you wouldn't know any better. It's only when you give Jill a chance you begin to notice how much easier her run is.
On the plus side, at least he doesn't have to put up with Barry's quips.