Uncharted 4: 20 Amazing Moments

Just when Nate thinks he's escaped trouble, he's attacked by Nadine, who holds nothing back as the two brawl. Her gun falls through a crack in the building, though, and Sam eventually joins Nate, making it a 2-on-1 slug-fest.

Nate tries to calm Nadine down by explaining that she'd be no match for the pair of them, but Nadine isn't one bit intimidated, easily beating the snot out of both brothers until Nate can sneak around the side of the building and punch her through the floor of a building, before Rafe shows up to diffuse the whole situation.

This sequence pretty much cemented Nadine as the best Uncharted villain, creating a strong female character who could plausibly hold her own against two athletic guys like Nate and Sam. So awesome.