Homer Simpson is a simple man. He is terribly unqualified for his job, and as far as he knows college is exactly like the movies he watches. Those films just happen to be ones in the vein of Animal House, where cool dudes team up with nerds to put stuffy deans in their place and objectify women. So when Homer is forced to go to college because of that aforementioned occupational incompetence, of course he assumes it will be just like his beloved college hijinks movies. The humour comes from the fact that, in reality, college is nothing like those films. The dean is a super nice guy, the college kids freak out when their punch is spiked, and when Homer asks his fellow jock if he got a load of that nerd, the student is quite confused. Homer Goes to College is all about riffing on the tropes of 80s collegiate sex comedies, and playing against them. Eventually, Homer ends up hanging out with the very nerds he was rallying against, and also hitting the dean with his car. A classic prank if there ever was one.
