10 Worst Things That Ever Happened To Deadpool
2. Lost His Chance To Have A Family - Deadpool (2012) #16
After a secret organization that was responsible for creating Deadpool targeted him alongside his fellow super-soldiers, Captain America and Logan, Wade ended up being taken to a rogue science camp in North Korea, where he found thousands of enslaved Korean men, women, and children who were fused with stolen powers from the X-Men and Deadpool's broken healing factor.
After being told about a woman he had met many years ago had given birth to a child that was most likely his, Wade shut down mentally, almost unable to escape. But thanks to the help of the other prisoners and his super pals, the camp was overthrown in a bloody uprising, during which the North Korean military began executing the families hidden in the mountainside base.
Wade and Cap were able to save some of the innocent families, but plenty more were burned alive by flamethrowers, including Deadpool's. His hope to meet a family he never knew about turned to literal ashes after finding the mother of his child dead inside a mass grave.