2. Daredevil
The Origin: A young Matt Murdoch is blinded by a radioactive substance, which falls from a passing truck and splashes into his eyes. Hes supported by his father; a two-bit boxer whos murdered after refusing to throw a fight theres your motivation right there. Despite being blind, Murdoch finds that his other senses have been heightened to near superhuman levels (presumably as a result of the exposure to radioactivity) and is even able to aurally perceive the world around him, by sensing vibration a supernatural form of sonar.
In Reality: Well, the good news is, Murdoch probably wouldnt have had to suffer through his fathers death. The bad news is that blindness would have been the least of his issues hed have been riddled with so much Leukaemia that hed have likely never got out of that hospital bed. Radioactivity doesnt interact with specific body parts; it doesnt morph whatever it touches into something bigger, stronger, better. That shit gets in your blood, messes with your very DNA and otherwise causes irreversible abnormalities and genetic mutations. And dont take mutations to mean mutants ala the X-Men genetic mutation is generally just a softer way of saying cancer.