9. Anthony Hopkins
MarvelCan't imagine this one being very likely, but boy, would it be great. It would be dismissive of his varied work to say the actor's finest performance was as Hannibal Lecter in Silence of the Lambs, but it is certainly one of his most prolific. His calm, yet subtly sinister performance in that film would make an excellent antagonist for a slow-burning survival horror title. Imagine the actor utilising his many talents to play a character not too dissimilar to the Mass Effect series' Illusive Man. One whose intentions are not immediately clear, with his origins and motivations being shrouded in mystery, yet still providing valuable advice and guidance to the player character. The alternate perspective of course, is having the acclaimed actor play an unwavering, sadistic mastermind who's only concern is the playful manipulation of human emotions to his character's own benefit. This talent isn't just evident in the Hannibal series either, films like Fracture have shown just how much Mr. Hopkins relishes the opportunity to play a depraved individual.