4. Marcus and Dominic (Gears of War Series)
If I'm being completely honest, I have never played a Gears of War game. I asked a few of my friends for suggestions on this list and every single one of them told me it would be blasphemy for me not to include this pair. I did my research - the little I could - and decided to put them where they are for what I've read. They're lifelong friends? Check. They cover for each other? Check. They'll go out of their way to make the other happy? Check. Everything just pointed in the direction of a true bromance. Marcus even became extremely depressed upon Dom's death as the other member's questioned his mental stability. Characterized by being extremely tough and thick-skinned, it seems his heart really was with his best friend and it broke when Dom decided to sacrifice himself. Just reading it made me sad. Imagine what it would do if I actually played it.