10 Video Game Features Only Hardcore Gamers Unlocked

The Binding of Isaac is a devious and poop-centric roguelike that doesn’t offer an easy ride at the best of times. The RNG factor means that a given run can be much easier or much harder, depending on the power-ups the player finds during the game.

One run, you’ll be flying and launching devastating eye-lasers at everything in sight, while the next, you might be leaving toxic puddles of pee on the floor for enemies to blunder onto.

Character choice has a huge impact on the game too. Some have an advantage over Isaac, such as higher HP, while The Lost seems to have simply been designed as a hard mode in and of itself.

The Lost doesn’t have any HP and can’t gain any, making completing already difficult tasks with them an absolute nightmare.

One such challenge is defeating Delirium, the ultimate final boss.

Doing so as The Lost will unlock the Holy Card, which gives the effects of Holy Mantle in one room (and has a chance to spawn another copy of itself). Potentially a very powerful card, but very difficult to unlock.