10. The Experimental MIRV - Fallout series
Have you grown bored with only firing one nuke at a time from your Fat Man?
How about launching 8 smaller nukes, like some kind of massive atom-powered shotgun?
The experimental MIRV (Multiple Impact Re-entry Vehicle) is a modified Fat Man that can be found in Fallout 3, 4, and 76. Equipping it allows you to fire 8 nukes that are not very accurate but make a lot of boom; in fact it's the most powerful weapon in the game.
There are drawbacks for anyone wanting to use the MIRV. It costs a couple thousand caps worth of ammo to launch it. If you use the VATS targeting system, as opposed to free-handing the weapon, you're likely to die yourself as VATS doesn't compensate for arc or range but just aims directly at your target.
The explosion is so powerful that if you fire the MIRV at the ground, it will fling your lifeless corpse the maximum height the game allows for. Also, if you plan on looting a group you MIRV, you'll have a hell of a time finding their bodies as they are also flung high into the air away from the target zone.
But watching it in action is something.