2. Hellboy
The agents of the Bureau of Paranormal Research and Defense are a wonderfully diverse and memorable group of misfits, perfectly in line with the precedent set by The Wolf Among Us. Again, we are dealing with global ramifications here, and Guillermo del Toro's films have already played with how Hellboy's choices put everyone else in harm's way. He often creates his own demons. Whether or not we end up playing as Hellboy, it's these sorts of big, important choices that have made Telltale games so fantastic in the past. There's also a uniquely eclectic group of people that your choices could affect, many of whom can throw fire at you if they don't like your choice, or merely hit you across the room.