9 Most Annoying Enemies In Video Game History

6. Masks And Hearts - Binding Of Isaac

last of us
Edmund McMillen

Binding of Isaac has plenty of irritating, not to mention extremely gross, enemies but the flying masks and hearts and their boss equivalent the Mask of Infamy are especially annoying.

You could be having a great run, well on your way to the womb. And then you enter a room with a group of these guys. Hope you have plenty of bombs.

Even worse is when you encounter them in rooms with layouts that make it hard to dodge, because this in combination with their seemingly endless capacity to absorb tears will leave you screaming 'STOP TURNING AND JUST DIE!' which can, apparently, be disconcerting for neighbours.

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