The biggest and most obvious thing that needs fixing - the game engine itself. Obviously ones to get the most out of their hard work, Bethesda have been using the same game engine for Elder Scrolls since Morrowind debuted it in 2002. For most of us it's rare you're going to pick up on such a thing unless it's very obvious, but with Skyrim the cracks were very much beginning to show in terms of trying to stretch the limitations on the ancient hardware to new extremes. We saw everything from backwards-flying dragons to headless quest-givers, companions sticking to walls or falling through the floor - even initially overpowered Giants whose club-strikes would essentially launch anything else into outer space. It was all supremely hilarious for the most part - and it is true that some fans love this sort of thing as a conceit of Bethesda's lofty vision for the series - but as the contending heir to the Western RPG crown Mass Effect has fallen on its sword, it's time for the programming heft to match up to that exquisite artistic vision.