Insomniac's Spider-Man 2: Every CONFIRMED Detail We Know
2. ...Complete With New Powers
During the sequence where Mary Jane infiltrates Norman's apartment (and picks up that second, fateful, radioactive spider), players are actually given their first tease of Miles' move-set.
Immediately to the right of the entrance, MJ can walk up to a desk and interact with a graph detailing two specific strains of Spider-DNA, one designed for active camouflage, and the other to emit an electro-kinetic blast. These are actually two of Miles' biggest powers, and it isn't exactly difficult to see how they'd work their way into the sequel's gameplay.
Whether this means we'll get to see Miles do more stealth sections or use a special 'venom blast' takedown is up in the air, but we can at least be certain that his move-set will differ from Peter's and that the game itself is likely to spotlight both Spider-Men, even as one of them potentially suits up in the symbiote and takes a somewhat darker turn.