Since he was first introduced in the pages of Amazing Fantasy #15 back in the early 1960s, Spider-Man has come face to face with some of the Marvel Universe's greatest villains. His rogues' gallery looks like a yearbook it has so many people in it, but you can't keep a good spider down - no matter how many enemies he has.
He's fought everything from burglars and muggers to world-dominating madmen and evil scientists. If a villain has some affiliation with an animal, you can pretty much bet on their being involved with Spider-Man, at least one time or another.
After all, this is the guy who fights foes called the Rhino, Vulture, and the Scorpion. Seeing as he's gone toe to toe with some of the Marvel Universe's biggest bads, his rogues gallery is filled to the brim with incredibly dangerous foes, and each one offers a different means of applying pressure on our Friendly Neighborhood Spider-Man.
Whichever villain he faces, Spider-Man is often pushed to his limit, and these ten bad guys represent the most dangerous foes he's ever faced. Some have unmasked him, some have even gone so far as to kill him, but Spidey keeps coming back to battle them, no matter the cost.
Jonathan is a graphic artist, illustrator, writer, and game designer. Jonathan retired from the U.S. Army in 2017 and enjoys researching and writing about history, science, theology, and many other subjects. He writes for ScreenRant, CBR, NerdBastards, Listverse, Ranker, WhatCulture, and many other sites online. You can check out his latest on Twitter: @TalkingBull or on his blog: jonathanhkantor.com