5. Chris Hardwick
One of the foremost nerds in the world today, you may know Chris Hardwick from any number of things. Perhaps one of his stand-up routines. Perhaps his voice acting work in Back At The Barnyard. Or perhaps one of his hosting gigs - Singled Out, Wired Science, Web Soup, Talking Dead, Ministry of Laughs, or his Nerdist Podcast. He also has the clout to be able to pull in some real heavyweight guests. Some of the guests he's had on his podcast alone are Drew Carey, Jon Hamm, Weird Al Yankovic, Craig Ferguson, Nathan Fillion, and Ozzy Osbourne. To name a few. If he can manage that with a podcast, just imagine what he could pull off on a nationally televised talk show.