Spider-Man 2: 10 Villain Boss Fights We Need To See

8. Mysterio

Mysterio Marvel
Marvel Comics

Mysterio might be more of an obvious choice than the previous two characters, given he's one of Spidey's most famous adversaries, but he's pretty much impossible to avoid if you're bringing Spider-Man to the video game medium.

That's largely because Mysterio, perhaps more than any other Spidey adversary, lends himself brilliantly to games in general. Quentin Beck is a master illusionist and is capable of making any of his targets question their own reality, utilising a variety of different gadgets and chemicals to turn an opponent's life upside down.

Mysterio could serve Insomniac in a similar way Scarecrow did Rocksteady for their seminal Batman: Arkham trilogy. Although absent for the second instalment, Scarecrow's nightmare segments were standout parts of both Arkham Asylum and Arkham Knight, and it's not difficult to imagine Insomniac applying similar lessons to Mysterio in their next Spidey title.

Content Producer/Presenter

WhatCulture's very own resident movie guy, Ewan has been working in the content creation biz for over 10 years now, having started as a freelance contributor to WhatCulture Gaming all the way back in 2015. After graduating with a First-Class Honours in History from Northumbria University in 2017 (where he won a prize for a totally killer dissertation on the Watergate years), Ewan took on the role of Comics Editor at WhatCulture and quickly developed WhatCulture Comics into one of the biggest superhero-focused channels on YouTube. He followed this with a brief hiatus at Screen Rant in 2021, where he worked across the Gaming and Film sections as a writer and editor, before returning to WhatCulture as a Senior Content Producer / Presenter in 2023. He started his own podcast, We Love Dad Movies, in 2022, and has contributed several written pieces to the Eisner-nominated comics website Shelfdust as well. In his current role, Ewan incorporates his love of cinema, comic books, and history into written pieces and video essays for WhatCulture's Film & TV channel, as well as WhatCulture Gaming and WhatCulture Horror, with a particular focus on nineties-era Dad Movies, old school Westerns, and Golden Age Hollywood Noir. John Carpenter is his fave, and he thinks Batman Beyond should never have been cancelled. If that's your vibe, you'll probably like his stuff.