3. The Prisoner with the Vortex Manipulator
Imagine the story line possibilities of this alone. The Doctor describes her as "hell in high heels" and with many good reasons. One of them could only be that she is more wickedly stubborn than he is. And the Vortex Manipulator may have only enabled her to do as she wants and try and follow the Doctor when/wherever she could. It already has been established that the Doctor know enough about her to know that she likes to dive off of high places and trusting he'll be there exactly when, where and how she needs him to be. A wife diving off a building trusting that her husband will be there to catch her only suggests that she may have been alone in most her adventures, but the Doctor will always be there when she asks. Acquiring the Vortex Manipulator, years after imprisonment, had now (in a future tense?) enabled her to escape the Stormcage Facility at will without having to wait that the Doctor comes to her doorstep. It definitely has given her the freedom, after considerable time adventuring with the Doctor, to go out into the Universe alone, no longer having to depend on the Doctor's whims on when those adventures happen. With the use of the Vortex Manipulator and her Timelord genes anything would most probably happen.